A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
نویسندگان
چکیده
OBJECTIVE To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years.
منابع مشابه
Response to Comment on: Chang et al. A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes. Diabetes Care 2012;35:2594–2596
We thank Dr. Dhatariya (1) for his interest in our recent article (2) and are pleased to have the opportunity to clarify the issues raised. Our primary aim was to evaluate the stability of gastric emptying over time in individuals with diabetes, and we found a remarkably strong relationship between the measurements of solid emptying obtained at baseline and some 25 years later. In other words, ...
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